System Choice I chose Ubuntu 18.04 LTS. Not any earlier version because to my knowledge most, if not all software for bioinformatics analysis will support 18.04. One exception to this is Nanopore’s Albacore base caller, but it is being replaced by Guppy anyways. 18.10 (the current highest version) was not chosen , because the improvements in features do not seem to justify an upgrade away from LTS.
Hardware GPU Ubuntu seems to dislike some high-spec GPUs.